ExploreInterventionOnabotulinumtoxinA 200 unit powder for solution for injection vial
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OnabotulinumtoxinA 200 unit powder for solution for injection vial

Also known as: OnabotulinumtoxinA 200 U (single cystoscopic intradetrusor injection) OnabotulinumtoxinA 200 unit lyophilised powder for solution for injection vial OnabotulinumtoxinA 200 unit lyophilized powder for solution for injection vial OnabotulinumtoxinA 200 unit powder for solution for injection vial Product containing precisely onabotulinumtoxinA 200 unit/1 vial lyophilized powder for conventional release solution for injection (clinical drug) Product containing precisely onabotulinumtoxinA 200 unit/1 vial powder for conventional release solution for injection (clinical drug)
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Findings (50)

None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA showed greater improvement than sacral neuromodulation in OAB symptom bother (-46.7 vs -38.6, mean difference 8.1, p=.002), treatment satisfaction (67.7 vs 59.8, mean difference 7.8

Effect: improvement; mean difference, 8.1 on OAB-q SF symptom bother; CI: 95% CI, 3.0 to 13.3

Size: mean difference, 8.1 on OAB-q SF symptom bother CI: 95% CI, 3.0 to 13.3
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14
None
improvement

OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.1

Effect: improvement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Size: mean difference, 0.63 episodes per day CI: 95% CI, 0.13 to 1.14

Papers (1)