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Finding
Finding
improvement
Longer duration of lactation was independently associated with lower 2-year incidence of type 2 diabetes after gestational diabetes pregnancy in a graded dose-response manner, with >10 months of breastfeeding showing a 57% relative risk reduction compared to 0-2 months.
| Effect size | HR 0.43 |
| CI | 95% CI 0.22-0.82 |
| Follow-up | 2 years |
| Comparator | 0 to 2 months of lactation |
| Effect summary | improvement; HR 0.43; CI: 95% CI 0.22-0.82 |
| Effect modifiers | [{"modifier": "Postpartum weight change (delivery to 1 year)", "interaction_p": "P trend = 0.044 after adding weight change as mediator", "direction": "attenuates", "stratum_details": "HR moved from 0.43 to 0.48 (>10 months duration) with addition of weight change \u2014 modest attenuation", "plain_language": "Weight loss explains a small part of why longer breastfeeding protects against diabetes, but most of the benefit comes from other biological mechanisms", "annotation_notes": "Tested as mediator. Attenuation modest and associations remained significant."}] |
Connected entities
Interventions
Outcomes
Populations
Source
PMC5193135
Lactation and Progression to Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus A Prospective Cohort Study