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Among 66,118 French women in the E3N-EPIC cohort, consumption of more than 603 mL/week of artificially sweetened beverages was associated with a 68% increase in 14-year diabetes risk compared to non-users, after extensive adjustment for BMI, diet, physical activity, family history, and other confounders.
Effect size68% increase in 14-year diabetes risk
Follow-up14 years
ComparatorNon-users of artificially sweetened beverages
Effect summarydecline; 68% increase in 14-year diabetes risk

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Source

PMC5045440
Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans
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