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Finding
Finding
improvement
Among 13 negative risk markers, a coronary artery calcium score of zero was the strongest for ruling out future coronary heart disease events over 10 years, resulting in a mean 59% relative reduction in pre-test to post-test CHD risk after adjustment for traditional risk factors.
| Effect size | DLR 0.41 (SD 0.12) for all CHD; DLR 0.36 (0.09) in men, 0.46 (0.12) in women |
| Follow-up | 10 years |
| Comparator | Pre-test risk based on traditional CVD risk factors alone (age, gender, smoking, diabetes, cholesterol, blood pressure, hypertension medication, race/ethnicity) without knowledge of CAC result |
| Effect summary | improvement; DLR 0.41 (SD 0.12) for all CHD; DLR 0.36 (0.09) in men, 0.46 (0.12) in women |
| Effect modifiers | [{"modifier": "sex", "interaction_p": "", "direction": "null", "stratum_details": "DLR for CHD: men 0.36 (0.09) vs women 0.46 (0.12). CAC=0 was strongest negative risk marker in both sexes.", "plain_language": "CAC=0 worked as a strong negative risk marker in both men and women, though it was slightly more informative in men.", "annotation_notes": ""}, {"modifier": "pre-test ASCVD risk level", "interaction_p": "", "direction": "attenuates", "stratum_details": "DLR for CVD: 0.47 (0.08) in high risk vs 0.67 (0.09) in low risk participants", "plain_language": "CAC=0 was more informative in higher-risk patients, where the relative risk reduction was greater, though it still downgraded risk meaningfully in lower-risk patients.", "annotation_notes": "CAC=0 was particularly informative at older ages and higher pre-test ASCVD risk."}] |
Connected entities
Interventions
Conditions
Source
PMC4775391
Role of Coronary Artery Calcium Score of Zero and Other Negative Risk Markers for Cardiovascular Disease: The Multi-Ethnic Study Of Atherosclerosis (MESA)