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Finding
Finding
improvement
Children breastfed during maternal AED therapy had higher adjusted IQ at age 6 years by 4 points compared to nonbreastfed children, with no adverse cognitive effects of AED exposure via breast milk.
| Effect size | adjusted IQ 4 points higher for breastfed children (regression coefficient 4.1) |
| CI | 95% CI, 0.1 to 8.1 |
| Follow-up | 7.2 months |
| Comparator | Children of women with epilepsy on AED monotherapy who were not breastfed |
| Effect summary | improvement; adjusted IQ 4 points higher for breastfed children (regression coefficient 4.1); CI: 95% CI, 0.1 to 8.1 |
| Effect modifiers | [{"modifier": "AED type (carbamazepine, lamotrigine, phenytoin, valproate)", "interaction_p": "", "direction": "null", "stratum_details": "Within each AED group, adjusted IQ was numerically higher for breastfed children (CBZ: breastfed 106 vs nonbreastfed 103; LTG: 108 vs 105; PHT: 108 vs 100; VPA: 97 vs 94), but power was inadequate within individual AED groups", "plain_language": "The breastfeeding benefit appeared similar regardless of which epilepsy drug the mother was taking, though the study was too small to confirm this for each drug individually.", "annotation_notes": "Power was 95% to detect 0.5-SD IQ effect in combined analysis but inadequate within groups"}] |
Connected entities
Conditions
Outcomes
Populations
Source
PMC4122685
Breastfeeding in Children of Women Taking Antiepileptic Drugs Cognitive Outcomes at Age 6 Years