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Finding
Finding
null
Candesartan preserved cerebrovascular reserve over 12 months (no significant within-group decline in vasoreactivity or VMR), whereas lisinopril and HCTZ groups showed significant declines. However, between-group comparisons did not reach statistical significance.
| Effect size | Between-group p=0.30 for vasoreactivity; p=0.46 for VMR |
| Follow-up | 12 months |
| Comparator | Lisinopril (10-40 mg/day) and hydrochlorothiazide (12.5-25 mg/day) |
| Effect summary | null; Between-group p=0.30 for vasoreactivity; p=0.46 for VMR |
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Source
PMC3608194
Antihypertensive therapy and cerebral hemodynamics in Executive Mild Cognitive Impairment: results of a Pilot randomized clinical trial