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Finding
Finding
decline
Comorbid lifetime anxiety disorder was associated with significantly lower smoking abstinence rates at end of treatment compared to no anxiety disorder, among smokers with unipolar depressive disorders receiving intensive cessation treatment.
| Effect size | 23% (18/79) vs 41% (49/120), Chi2=6.9, p<0.01 |
| Comparator | Participants without lifetime anxiety disorder receiving the same treatment |
| Effect summary | decline; 23% (18/79) vs 41% (49/120), Chi2=6.9, p<0.01 |
| Effect modifiers | [{"modifier": "Baseline depression severity (HAM-D-6 >4)", "interaction_p": "", "direction": "amplifies", "stratum_details": "The effect of anxiety disorder on abstinence was seen particularly in the 111 subjects with high depression symptoms (HAMD-6 >4) at screen.", "plain_language": "Having both high depression symptoms and an anxiety disorder made it even harder to quit smoking", "annotation_notes": "Interaction not formally tested, described as 'particularly' seen in high depression subgroup"}] |
Connected entities
Interventions
Conditions
Source
PMC3505846
A Controlled Trial of Bupropion Added to Nicotine Patch and Behavioral Therapy for Smoking Cessation in Adults with Unipolar Depressive Disorders