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Finding
Finding
improvement
Among women with a positive preoperative prolapse-reduction stress test, the sling appeared to provide greater benefit at 3 months (29.6% vs 71.9% incontinence, adjusted OR 0.13, 95% CI 0.05 to 0.34) than among those with a negative test, though the interaction was borderline at 3 months (p=0.06) and not significant at 12 months (p=0.16).
| Effect size | Positive stress test: 29.6% sling vs 71.9% sham, adjusted OR 0.13 |
| CI | 95% CI 0.05 to 0.34 |
| Follow-up | 12 months |
| Comparator | Sham incisions, stratified by preoperative stress test result |
| Effect summary | improvement; Positive stress test: 29.6% sling vs 71.9% sham, adjusted OR 0.13; CI: 95% CI 0.05 to 0.34 |
| Effect modifiers | [{"modifier": "Preoperative prolapse-reduction stress test result", "interaction_p": "p=0.06 at 3 months; p=0.16 at 12 months", "direction": "null", "stratum_details": "Positive test (33.5%): sling OR 0.13 (95% CI 0.05-0.34) at 3 months. Negative test: smaller benefit. Interaction not significant.", "plain_language": "A preoperative stress test showing hidden incontinence suggests you might benefit more from a sling, but this study could not prove the test reliably predicts who benefits most.", "annotation_notes": "The interaction was borderline at 3 months and disappeared at 12 months. The authors note that 'this difference was not significant at 12 months.' Clinically, the stress test is still used to guide counseling but this study does not validate it as a reliable predictor of differential benefit."}] |
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Source
PMC3433843
A Midurethral Sling to Reduce Incontinence after Vaginal Prolapse Repair