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Higher doses of SSRIs were associated with significantly higher proportion of dropouts due to side effects compared to placebo and low-dose SSRI, though the increased side-effect burden was somewhat counterbalanced by increased efficacy as measured by all-cause discontinuation.
Effect sizeARD=0.07, NNH=14.3 (high vs placebo); ARD=0.05, NNH=16.7 (high vs low dose)
CI95% CI: 0.03-0.11, NNH 95% CI: 9.9-50.0 (vs placebo); 95% CI: 0.01-0.09, NNH 95% CI: 11.1-100 (vs low dose)
Follow-up8-13 weeks
ComparatorPlacebo and low-dose SSRI pharmacotherapy
Effect summaryadverse; ARD=0.07, NNH=14.3 (high vs placebo); ARD=0.05, NNH=16.7 (high vs low dose); CI: 95% CI: 0.03-0.11, NNH 95% CI: 9.9-50.0 (vs placebo); 95% CI: 0.01-0.09, NNH 95% CI: 11.1-100 (vs low dose)
Adverse eventsdropouts due to side effects, high dose ARD=0.07, medium dose ARD=0.06, low dose ARD=0.05

Connected entities

Interventions
SSRI pharmacotherapy
Conditions
Obsessive-Compulsive Disorder
Outcomes
Dropout rate due to side effects

Source

PMC2888928
Meta-Analysis of the Dose-Response Relationship of SSRI in Obsessive-Compulsive Disorder
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