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Finding
Finding
improvement
High-dose SSRI pharmacotherapy showed significantly greater improvement in Y-BOCS score than both low-dose (WMD=2.1, p<0.001) and medium-dose (WMD=1.8, p=0.001) SSRI, and higher treatment response rates than both low (ARD=0.07, p<0.05) and medium (ARD=0.08, p=0.02) doses, supporting the use of higher SSRI doses in OCD treatment.
| Effect size | WMD=3.9 (95% CI: 2.9-4.9) vs placebo for Y-BOCS change; ARD=0.22 (95% CI: 0.16-0.28) for treatment response vs placebo |
| CI | 95% CI: 2.9-4.9 (Y-BOCS WMD vs placebo); 95% CI: 0.16-0.28 (ARD treatment response vs placebo) |
| Follow-up | 8-13 weeks |
| Comparator | Low-dose SSRI and medium-dose SSRI (secondary comparisons), placebo (primary comparison) |
| Effect summary | improvement; WMD=3.9 (95% CI: 2.9-4.9) vs placebo for Y-BOCS change; ARD=0.22 (95% CI: 0.16-0.28) for treatment response vs placebo; CI: 95% CI: 2.9-4.9 (Y-BOCS WMD vs placebo); 95% CI: 0.16-0.28 (ARD treatment response vs placebo) |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC2888928
Meta-Analysis of the Dose-Response Relationship of SSRI in Obsessive-Compulsive Disorder