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Finding adverse
Deep brain stimulation was associated with small but statistically significant decrements in working memory, processing speed, phonemic fluency, and visuospatial delayed recall compared with best medical therapy, which showed slight improvements.
Effect size1.0 to 3.5-point decreases in DBS group vs 1 to 2-point increases in BMT group on composite measures
Follow-up6 months
ComparatorBest medical therapy actively managed by movement disorder neurologists
Effect summaryadverse; 1.0 to 3.5-point decreases in DBS group vs 1 to 2-point increases in BMT group on composite measures
Adverse eventsmild decrements in performance (1.0- to 3.5-point decreases)

Connected entities

Interventions
Bilateral deep sclerectomy
Conditions
advanced Parkinson disease with motor complications
Outcomes
Neurocognitive function
Populations
Older Adults

Source

PMC2814800
Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson Disease A Randomized Controlled Trial
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