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Finding
Finding
adverse
Glycemic load was significantly associated with elevated breast cancer risk in premenopausal women, with the fourth quintile showing a hazard ratio of 1.63 compared to the lowest quintile (95% CI 1.07-2.48, p for trend=0.008), consistent with the high correlation between glycemic load and total carbohydrate intake (r=0.95).
| Effect size | HR 1.63 (Q4 vs Q1) |
| CI | 95% CI (1.07, 2.48) |
| Comparator | Lowest quintile of energy-adjusted glycemic load (median 163.8) |
| Effect summary | adverse; HR 1.63 (Q4 vs Q1); CI: 95% CI (1.07, 2.48) |
| Effect modifiers | [{"modifier": "menopausal status", "interaction_p": "p=0.007", "direction": "reverses", "stratum_details": "Premenopausal: HR 1.63 Q4 vs Q1 (p-trend=0.008); Postmenopausal: no significant association (p-trend=0.285)", "plain_language": "The glycemic load-breast cancer link only showed up in women who hadn't gone through menopause yet. After menopause, how much your food spiked blood sugar didn't matter for breast cancer risk.", "annotation_notes": "Glycemic load highly correlated with total carbohydrate intake (r=0.95)"}] |
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Source
PMC2630482
Dietary carbohydrates, fiber, and breast cancer risk in Chinese women