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Finding
Finding
decline
Obesity was independently associated with inferior OS, inferior DFS, increased relapse, and increased NRM in AYAs with Ph-negative ALL, regardless of whether they received chemotherapy or HCT.
| Effect size | HR 2.17 (obese vs non-obese, OS) |
| CI | 95% CI 1.63–2.89 |
| Comparator | Non-obese AYAs (BMI <30 kg/m2) with Ph-negative ALL |
| Effect summary | decline; HR 2.17 (obese vs non-obese, OS); CI: 95% CI 1.63–2.89 |
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Source
PMC8257494
Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: Analysis from CALGB 10403 and the CIBMTR