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Finding
Finding
decline
Pediatric-style chemotherapy was associated with higher 5-year cumulative relapse incidence compared to allogeneic HCT, though the timing of relapse differed: relapse was initially more likely with HCT in the first 15 months, then more likely with chemotherapy after 15 months.
| Effect size | 5-year relapse 34% vs 23% |
| Follow-up | 5 years |
| Comparator | Myeloablative allogeneic hematopoietic cell transplantation (CIBMTR cohort) |
| Effect summary | decline; 5-year relapse 34% vs 23% |
Connected entities
Interventions
Conditions
Outcomes
Populations
Source
PMC8257494
Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: Analysis from CALGB 10403 and the CIBMTR