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Finding improvement
Pediatric-style chemotherapy produced superior disease-free survival compared to myeloablative allogeneic HCT in AYAs with Ph-negative ALL in CR1.
Effect sizeHR 1.62 (HCT vs chemotherapy)
CI95% CI 1.25–2.12
ComparatorMyeloablative allogeneic hematopoietic cell transplantation (CIBMTR cohort)
Effect summaryimprovement; HR 1.62 (HCT vs chemotherapy); CI: 95% CI 1.25–2.12

Connected entities

Interventions
post-remission chemotherapy
Conditions
Ph-negative acute lymphoblastic leukemia
Outcomes
Disease-Free Survival
Populations
Adolescents

Source

PMC8257494
Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: Analysis from CALGB 10403 and the CIBMTR
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