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Finding improvement
Pediatric-style post-remission chemotherapy produced superior overall survival compared to myeloablative allogeneic HCT in AYAs with Ph-negative ALL in CR1, with 5-year OS of 66% vs 47%.
Effect sizeHR 2.00 (HCT vs chemotherapy)
CI95% CI 1.5–2.66
Follow-up5 years
ComparatorMyeloablative allogeneic hematopoietic cell transplantation from matched sibling, matched related, or unrelated donor (CIBMTR cohort, 92% TBI-based conditioning)
Effect summaryimprovement; HR 2.00 (HCT vs chemotherapy); CI: 95% CI 1.5–2.66

Connected entities

Interventions
post-remission chemotherapy
Conditions
Ph-negative acute lymphoblastic leukemia
Outcomes
Overall survival
Populations
Adolescents

Source

PMC8257494
Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: Analysis from CALGB 10403 and the CIBMTR
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