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Finding null
Baseline CRP and sICAM-1 were associated with incident diabetes in the placebo group after demographic adjustment but lost significance after adjustment for traditional diabetes risk factors, indicating these associations are explained by obesity, insulin resistance, and dysglycaemia rather than independent pathways.
Effect sizeCRP and sICAM-1 significant only in demographics-adjusted models, attenuated to non-significance after DRF adjustment
Comparatorper 1 SD increase in baseline CRP or sICAM-1 (placebo group, adjusted for DRFs)
Effect summarynull; CRP and sICAM-1 significant only in demographics-adjusted models, attenuated to non-significance after DRF adjustment

Connected entities

Interventions
CRP and sICAM-1 levels
Conditions
Alloxan Diabetes
Outcomes
Risk of

Source

PMC6456055
Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions
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