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Finding
Finding
decline
Higher baseline leptin was directly and robustly associated with incident diabetes in the lifestyle group only, independent of diabetes risk factors including BMI, a novel association not seen in placebo or metformin groups.
| Effect size | HR 1.31 |
| CI | 95% CI 1.06, 1.63 |
| Follow-up | 1 year |
| Comparator | per 1 SD increase in baseline leptin (ILS group only; no association in placebo or metformin groups) |
| Effect summary | decline; HR 1.31; CI: 95% CI 1.06, 1.63 |
| Effect modifiers | [{"modifier": "treatment group (ILS vs placebo/metformin)", "interaction_p": "heterogeneity by group present", "direction": "amplifies", "stratum_details": "Leptin HR 1.31 (1.06-1.63) in ILS group vs non-significant in placebo and metformin groups", "plain_language": "High leptin predicted diabetes only in people doing the lifestyle program, not in those on metformin or standard care.", "annotation_notes": "This is an intervention-emergent association: the lifestyle intervention exposed a subgroup with high leptin who were relatively resistant to ILS benefits. Authors suggest this represents a hyperleptinaemic subgroup that deserves targeted investigation."}] |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC6456055
Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions