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Finding decline
Higher baseline tPA was associated with increased incident diabetes risk in the placebo group, independent of traditional diabetes risk factors and their 1-year changes, and independent of all other biomarkers.
Effect sizeHR 1.13
CI95% CI 1.03, 1.24
Follow-up1 year
Comparatorper 1 SD increase in baseline tPA (placebo/standard care group)
Effect summarydecline; HR 1.13; CI: 95% CI 1.03, 1.24

Connected entities

Interventions
tPA level
Conditions
Alloxan Diabetes
Outcomes
Risk of

Source

PMC6456055
Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions
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