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Finding
Finding
null
Chemotherapy treatment intensity (HDMTX exposure, intrathecal therapy doses, and cumulative dexamethasone dose) was not associated with any child self-reported or parent-reported behavioral symptoms or psychiatric disorders, suggesting the cancer experience rather than treatment itself contributes to behavioral problems.
| Effect size | RR 0.98 (95% CI 0.96-1.01) for HDMTX AUC on inattention; all p-values > 0.05 after FDR correction across all treatment-outcome combinations |
| Comparator | Within-sample variation in chemotherapy dose intensity |
| Effect summary | null; RR 0.98 (95% CI 0.96-1.01) for HDMTX AUC on inattention; all p-values > 0.05 after FDR correction across all treatment-outcome combinations |
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Source
PMC5986588
Behavioral Symptoms and Psychiatric Disorders in Child and Adolescent Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia Treated with Chemotherapy Only