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Finding
Finding
adverse
Among atrial fibrillation patients under 60 with no structural heart disease and stroke risk scores of zero, approximately one in four (23.3-26.6%) were prescribed oral anticoagulants despite guidelines recommending avoidance, exposing them to bleeding risks without corresponding benefit.
| Effect size | 23.3% (CHADS2 cohort) and 26.6% (CHA2DS2-VASc cohort) prescribed oral anticoagulants |
| Comparator | Guideline recommendation to avoid anticoagulation in patients with CHADS2/CHA2DS2-VASc score of 0 |
| Effect summary | adverse; 23.3% (CHADS2 cohort) and 26.6% (CHA2DS2-VASc cohort) prescribed oral anticoagulants |
| Adverse events | bleeding risks |
| Effect modifiers | [{"modifier": "Age", "interaction_p": "", "direction": "amplifies", "stratum_details": "Patients prescribed anticoagulants were older (mean age 51) within the <60 cohort", "plain_language": "Older patients within this low-risk group were more likely to be inappropriately prescribed blood thinners", "annotation_notes": ""}, {"modifier": "BMI", "interaction_p": "", "direction": "amplifies", "stratum_details": "Higher BMI was associated with anticoagulant prescribing", "plain_language": "Heavier patients were more likely to get unnecessary blood thinners", "annotation_notes": ""}, {"modifier": "Insurance status", "interaction_p": "", "direction": "amplifies", "stratum_details": "More frequently insured by Medicare or uninsured", "plain_language": "Medicare beneficiaries and uninsured patients were more likely to receive unnecessary blood thinners", "annotation_notes": ""}, {"modifier": "Atrial fibrillation type (paroxysmal)", "interaction_p": "", "direction": "attenuates", "stratum_details": "Patients with paroxysmal AF were less likely to receive anticoagulants", "plain_language": "Patients whose irregular heartbeat came and went were less likely to get unnecessary blood thinners than those with constant irregular heartbeat", "annotation_notes": ""}] |
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