Explore ›
Finding
Finding
adverse
The ABFM regimen in AYA patients caused significant asparaginase-related toxicities including grade 3-4 hepatotoxicity in 41%, pancreatitis in 11%, osteonecrosis in 9%, thrombosis in 19%, and severe allergic reactions to PEG-asparaginase in 19%.
| Effect size | Grade 3-4 liver enzyme elevations in 41% |
| Comparator | Hyper-CVAD regimen (which had predominantly myelosuppression-related toxicity instead) |
| Effect summary | adverse; Grade 3-4 liver enzyme elevations in 41% |
| Adverse events | grade 3–4 hyperbilirubinemia 38%, grade 3–4 liver enzyme elevations 41%, hypofibrinogenemia 35%, thrombosis 19%, severe allergic reactions to PEG-asparaginase 19%, pancreatitis 11%, osteonecrosis 9% |
Connected entities
Conditions
Outcomes
Populations
Source
PMC5558853
Final results of a single institution experience with a pediatric-based regimen, the augmented Berlin–Frankfurt–Münster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper-CVAD regimen