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Finding
Finding
decline
Across multiple large-scale, long-term prospective observational studies in humans, daily or more frequent consumption of diet sodas and other LCS-sweetened beverages was associated with significantly increased risk of hypertension, metabolic syndrome, diabetes, depression, kidney dysfunction, cardiovascular events, cardiovascular mortality, and overall mortality, even after controlling for baseline BMI, caloric intake, physical activity, and other confounders.
| Effect size | 14% increased hypertension; 23-53% increased metabolic syndrome; 38-68% increased diabetes; 30-43% increased cardiovascular events; 50% increased cardiovascular mortality; 30% increased overall mortality |
| Comparator | Non-users or infrequent users of diet sodas/ASBs |
| Effect summary | decline; 14% increased hypertension; 23-53% increased metabolic syndrome; 38-68% increased diabetes; 30-43% increased cardiovascular events; 50% increased cardiovascular mortality; 30% increased overall mortality |
| Adverse events | 14% increased hypertension, 59% increased waist circumference, 23-53% increased metabolic syndrome, 38-68% increased diabetes, 31% increased depression, doubling of kidney function decline, 27% greater hazard of hemorrhagic stroke, 30-43% greater risk of cardiovascular events, 50% increased cardiovascular mortality, 30% increased overall mortality |
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Source
PMC5045440
Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans