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Finding
Finding
improvement
CABG resulted in slightly greater angina frequency relief than DES-PCI at the 1-year and 2-year follow-up time points, with a mean treatment benefit of 1.3 points on the SAQ-AF subscale at 24 months (p=0.01), though this difference was well below the 8-10 point threshold for clinical meaningfulness.
| Effect size | 1.3 points (CABG-PCI difference at 24 months) |
| CI | 95% CI 0.3 to 2.2 |
| Follow-up | 3 years |
| Comparator | Percutaneous coronary intervention using drug-eluting stents (DES-PCI) |
| Effect summary | improvement; 1.3 points (CABG-PCI difference at 24 months); CI: 95% CI 0.3 to 2.2 |
| Effect modifiers | [{"modifier": "SYNTAX score", "interaction_p": "significant interaction (p not reported for AF specifically; see Finding 7 for details)", "direction": "amplifies", "stratum_details": "Intermediate SYNTAX (23-32): 2.8 point CABG benefit at 1 year; low SYNTAX (<=22): -0.1; high SYNTAX (>=33): 0.3", "plain_language": "Patients with moderately complex blockages got the most angina relief from bypass surgery compared to stents. Those with simpler or the most complex blockages saw no difference.", "annotation_notes": "Full subgroup details captured in separate finding CABG-VS-PCI-SUBGROUP-SYNTAX-2013"}, {"modifier": "Baseline angina severity", "interaction_p": "significant interaction (p not reported for AF specifically; see Finding 8 for details)", "direction": "amplifies", "stratum_details": "Daily/weekly angina: 1.8 point CABG benefit; monthly: 1.3; none: -0.9 (favoring PCI)", "plain_language": "Patients with the worst chest pain before surgery benefited most from bypass over stents for angina relief. Patients without chest pain actually did slightly better with stents.", "annotation_notes": "Full subgroup details captured in separate finding CABG-VS-PCI-SUBGROUP-BASELINE-ANGINA-2013"}, {"modifier": "Age", "interaction_p": "", "direction": "null", "stratum_details": "No significant heterogeneity across age groups (<65, 65-75, >75)", "plain_language": "Age did not affect whether bypass or stents gave better angina relief.", "annotation_notes": "Prespecified subgroup"}, {"modifier": "Sex", "interaction_p": "", "direction": "null", "stratum_details": "No significant heterogeneity by sex", "plain_language": "Men and women benefited similarly.", "annotation_notes": "Prespecified subgroup"}, {"modifier": "Number of diseased vessels", "interaction_p": "", "direction": "null", "stratum_details": "No significant heterogeneity", "plain_language": "Whether patients had blockages in 2 or 3 arteries did not change the result.", "annotation_notes": "Prespecified subgroup"}, {"modifier": "LAD involvement (>70% stenosis)", "interaction_p": "", "direction": "null", "stratum_details": "No significant heterogeneity", "plain_language": "Having a major blockage in the main artery on the front of the heart did not change the result.", "annotation_notes": "Prespecified subgroup"}] |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC4370776
Quality of Life after PCI vs. CABG among Patients with Diabetes and Multivessel CAD: Results from the FREEDOM Trial