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Finding
Finding
adverse
Fetal valproate exposure was associated with lower IQ at age 6 years compared to other AEDs, with adjusted IQ 7-13 points worse, in a dose-dependent manner.
| Effect size | adjusted IQ worse by 7-13 IQ points for valproate compared to other drugs |
| Comparator | Children exposed in utero to carbamazepine, lamotrigine, or phenytoin monotherapy |
| Effect summary | adverse; adjusted IQ worse by 7-13 IQ points for valproate compared to other drugs |
| Adverse events | major congenital malformations, cognitive impairments |
Connected entities
Interventions
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Outcomes
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Source
PMC4122685
Breastfeeding in Children of Women Taking Antiepileptic Drugs Cognitive Outcomes at Age 6 Years