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Finding
Finding
improvement
After delivery, lamotrigine oral clearance declined exponentially back to pre-pregnancy baseline values with a half-life of 0.55 weeks, meaning doses should be tapered to preconception levels within 3 weeks to avoid toxicity.
| Effect size | CL/F return half-life 0.55 weeks (rate constant k=1.27/week) |
| Follow-up | 3 weeks |
| Comparator | Peak pregnancy lamotrigine oral clearance |
| Effect summary | improvement; CL/F return half-life 0.55 weeks (rate constant k=1.27/week) |
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Source
PMC4038031
MODEL-BASED LAMOTRIGINE CLEARANCE CHANGES DURING PREGNANCY: CLINICAL IMPLICATION