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Finding
Finding
null
There was no statistically significant association between serum taurine levels and overall CHD risk. The adjusted odds ratio for CHD in the highest versus lowest tertile of serum taurine was 0.66 (95% CI 0.39-1.13, p for trend = 0.14).
| Effect size | OR 0.66 |
| CI | 95% CI 0.39-1.13 |
| Comparator | Lowest tertile of serum taurine (reference group) |
| Effect summary | null; OR 0.66; CI: 95% CI 0.39-1.13 |
| Effect modifiers | [{"modifier": "Total serum cholesterol", "interaction_p": "p = 0.01", "direction": "amplifies", "stratum_details": "Among women with high cholesterol (>250 mg/dl): OR 0.39 (95% CI 0.19-0.83) for 3rd vs 1st tertile, p for trend=0.02. No association in low cholesterol group.", "plain_language": "Taurine appeared protective against heart disease only in women who already had high cholesterol levels. In women with normal cholesterol, taurine made no difference.", "annotation_notes": "This is the primary subgroup finding of the paper. Biological rationale: taurine's antioxidant properties may counteract oxidized LDL from hypercholesterolemia."}, {"modifier": "Smoking status", "interaction_p": "p = 0.25", "direction": "null", "stratum_details": "Inverse association stronger among never smokers (p for trend=0.09) vs ever smokers (p for trend=0.77), but no significant interaction on multiplicative scale.", "plain_language": "The protective trend was slightly stronger in never-smokers, but this difference was not statistically significant.", "annotation_notes": "Non-significant interaction. Reported in Table 3."}, {"modifier": "BMI", "interaction_p": "p = 0.27", "direction": "null", "stratum_details": "Association did not differ by BMI (<=25 vs >25 kg/m2).", "plain_language": "Body weight did not affect whether taurine was protective or not.", "annotation_notes": "Non-significant interaction. Reported in Table 3."}] |
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Source
PMC3920833
Serum taurine and risk of coronary heart disease: a prospective, nested case-control study