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Finding decline
Among smokers with unipolar depressive disorders who entered the trial with low depressive symptoms, achieving smoking abstinence was associated with a significantly higher rate of worsening depressive symptoms compared to not achieving abstinence.
Effect size56% (35/63) vs 27% (6/22), Chi2=4.60, p=0.032
ComparatorNon-abstinent participants with low baseline depressive symptoms
Effect summarydecline; 56% (35/63) vs 27% (6/22), Chi2=4.60, p=0.032

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Source

PMC3505846
A Controlled Trial of Bupropion Added to Nicotine Patch and Behavioral Therapy for Smoking Cessation in Adults with Unipolar Depressive Disorders
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