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Finding
Finding
decline
Among couples undergoing ICSI, the odds of live birth in couples with obese male partners were 84% (95% CI 10%-97%) lower than the odds in couples with male partners with normal BMI (p-trend=0.04), an association that persisted after adjustment for semen quality parameters.
| Effect size | 84% lower odds of live birth (OR 0.16) |
| CI | 95% CI 3%-90% (equivalently, odds reduction 10%-97%) |
| Comparator | Normal weight men (BMI 18.5-24.9 kg/m2) |
| Effect summary | decline; 84% lower odds of live birth (OR 0.16); CI: 95% CI 3%-90% (equivalently, odds reduction 10%-97%) |
| Effect modifiers | [{"modifier": "fertilization technique (IVF vs ICSI)", "interaction_p": "p=0.04", "direction": "reverses", "stratum_details": "ICSI: 84% lower odds of live birth with male obesity (95% CI 10%-97%, p-trend=0.04); Conventional IVF: suggestion of higher live birth rates with increasing male BMI (not statistically significant)", "plain_language": "Male obesity hurt live birth chances only for couples using ICSI (where sperm is injected directly into the egg). For couples using conventional IVF (where sperm fertilize eggs naturally in a dish), male weight did not significantly affect live birth rates.", "annotation_notes": "p-heterogeneity=0.04 for the interaction between male BMI and cycle type on live birth"}, {"modifier": "female BMI", "interaction_p": "not significant", "direction": "null", "stratum_details": "No evidence of effect modification by female BMI on the association between male BMI and clinical outcomes", "plain_language": "The woman's weight did not change whether the man's weight affected IVF results.", "annotation_notes": ""}, {"modifier": "infertility diagnosis", "interaction_p": "not significant", "direction": "null", "stratum_details": "No evidence of effect modification by infertility diagnosis on the association between male BMI and clinical outcomes", "plain_language": "The reason for the couple's infertility did not change whether the man's weight mattered.", "annotation_notes": ""}] |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC3478419
MEN’S BODY MASS INDEX IN RELATION TO EMBRYO QUALITY AND CLINICAL OUTCOMES IN COUPLES UNDERGOING IN VITRO FERTILIZATION