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Finding decline
Pediatric APL patients with FLT3 mutations had a dramatically higher rate of high diagnostic WBC count (>10,000 cells/uL) at 70% compared to 26% in FLT3 wild-type patients, with median WBC of 32,950 vs 3,600 cells/uL.
Effect size70% vs 26%
ComparatorFLT3 wild-type (FLT3/WT) pediatric APL patients on CALGB C9710
Effect summarydecline; 70% vs 26%

Connected entities

Interventions
FLT3 mutation testing
Conditions
Pediatric acute epiglottitis and supraglottitis
Outcomes
Association
Populations
Children

Source

PMC3368997
FLT3 Mutation Status is a Predictor of Early Death in Pediatric Acute Promyelocytic Leukemia: A Report From The Children's Oncology Group
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