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Finding decline
Pediatric APL patients with FLT3 mutations had a significantly lower complete remission rate after first induction (60%) compared to FLT3 wild-type patients (93%), driven primarily by induction deaths rather than refractory disease.
Effect size60% vs 93%
ComparatorFLT3 wild-type (FLT3/WT) pediatric APL patients on CALGB C9710
Effect summarydecline; 60% vs 93%

Connected entities

Interventions
FLT3 mutation testing
Conditions
Pediatric acute epiglottitis and supraglottitis
Outcomes
Acute myeloid leukemia in complete remission
Populations
Children

Source

PMC3368997
FLT3 Mutation Status is a Predictor of Early Death in Pediatric Acute Promyelocytic Leukemia: A Report From The Children's Oncology Group
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