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Finding null
Anti-miR-33 treatment produced no difference in total plasma cholesterol or LDL cholesterol between treatment and control groups over 12 weeks, demonstrating that the HDL-raising effect is selective and does not alter LDL or total cholesterol.
Effect sizeno difference between groups
Follow-up12 weeks
ComparatorMismatch control antisense oligonucleotide (same dose, same schedule)
Effect summarynull; no difference between groups

Connected entities

Interventions
Anti-miR-33 antisense oligonucleotide
Conditions
Dyslipidemia
Outcomes
Porphyrin measurement, total, plasma

Source

PMC3235584
Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides
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