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Finding
Finding
improvement
Patients using statins at stroke onset had significantly greater neurological improvement from admission to 1 month compared to patients not using statins, as measured by change in NIH Stroke Scale.
| Effect size | 8.8±4.0 points vs 4.4±5.7 points, p=0.028 |
| Follow-up | 1 month |
| Comparator | No statin use at stroke onset (n=19) |
| Effect summary | improvement; 8.8±4.0 points vs 4.4±5.7 points, p=0.028 |
| Effect modifiers | [{"modifier": "Age", "interaction_p": "", "direction": "null", "stratum_details": "Age independently predicted NIHSS improvement: \u03b2(SE) = \u22120.163(0.06), p=0.015. Interaction between statin use and age was assessed.", "plain_language": "Younger patients improved more, but age did not change the statin benefit itself.", "annotation_notes": "Age was a significant covariate in the final model but the statin-age interaction was tested and not significant per the methods."}, {"modifier": "tPA treatment", "interaction_p": "", "direction": "null", "stratum_details": "Statin effect persisted in tPA-treated subgroup: delta-NIHSS 8.9\u00b14.2 vs 4.4\u00b14.9, p=0.048. Interaction between statin use and tPA was assessed.", "plain_language": "The neurological benefit of statins held up regardless of whether patients also received tPA.", "annotation_notes": "tPA interaction assessed per methods section."}] |
Connected entities
Conditions
Outcomes
Source
PMC3125694
Pre-existing Statin Use is Associated with Greater Reperfusion in Hyper-Acute Ischemic Stroke