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Finding
Finding
improvement
Patients using statins prior to ischemic stroke onset had significantly greater early cerebral reperfusion within 6 hours compared to patients not taking statins, with a 2-3-fold difference across all MTT thresholds examined.
| Effect size | median relative reperfusion 50% (IQR 30%,56%) vs 13% (IQR=5%,36%), p=0.014 |
| Follow-up | 6 hours |
| Comparator | No statin use at stroke onset (n=19) |
| Effect summary | improvement; median relative reperfusion 50% (IQR 30%,56%) vs 13% (IQR=5%,36%), p=0.014 |
| Effect modifiers | [{"modifier": "tPA treatment", "interaction_p": "", "direction": "null", "stratum_details": "Statin effect persisted in tPA-treated subgroup (n=23): median reperfusion 48% vs 15%. Interaction between statin use and tPA treatment assessed and not significant.", "plain_language": "The benefit of statins on reperfusion held up regardless of whether patients also received the clot-busting drug tPA.", "annotation_notes": "Authors specifically analyzed tPA subgroup because more statin patients received tPA; interaction was tested and not significant."}, {"modifier": "Mean arterial pressure (MAP)", "interaction_p": "", "direction": "null", "stratum_details": "MAP interaction with statin use assessed and not significant. MAP independently predicted reperfusion: \u03b2(SE) = \u22120.318(0.15), p=0.040.", "plain_language": "Blood pressure at admission did not change the statin effect on reperfusion, although higher blood pressure independently predicted less reperfusion.", "annotation_notes": "MAP was an independent predictor of reperfusion in the final model but did not interact with statin use."}] |
Connected entities
Conditions
Outcomes
Source
PMC3125694
Pre-existing Statin Use is Associated with Greater Reperfusion in Hyper-Acute Ischemic Stroke