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Finding null
In the MGH study (N=125), no HAM-D-17 anxiety/somatization item reached significance after Bonferroni correction in any treatment arm (fluoxetine, hypericum, or placebo), despite nominal significance for anxiety-psychic in the fluoxetine arm (p=0.026) and somatic-GI in the hypericum arm (p=0.042).
Effect sizebest: anxiety-psychic in fluoxetine arm p=0.026; somatic-GI in hypericum arm p=0.042
Follow-up12 weeks
ComparatorNon-improvement in anxiety/somatization items at week 1 within each MGH treatment arm
Effect summarynull; best: anxiety-psychic in fluoxetine arm p=0.026; somatic-GI in hypericum arm p=0.042

Connected entities

Interventions
Hypericum
Conditions
Major Depressive Disorder
Outcomes
Remission

Source

PMC3111899
Do early changes in the HAM-D-17 anxiety/somatization factor items affect treatment outcome among depressed outpatients? Comparison of two controlled trials of St John’s Wort (Hypericum Perforatum) versus an SSRI
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