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Finding improvement
In the pooled placebo arms (n=153), early improvement in anxiety-psychic (p=0.003, r2=0.110) and somatic symptoms-general (p=0.001, r2=0.118) items from baseline to week 1 significantly predicted remission at endpoint, and both survived Bonferroni correction.
Effect sizeanxiety-psychic: p=0.003, r2=0.110; somatic-general: p=0.001, r2=0.118
ComparatorNon-improvement in anxiety-psychic/somatic-general items at week 1 within the placebo group
Effect summaryimprovement; anxiety-psychic: p=0.003, r2=0.110; somatic-general: p=0.001, r2=0.118

Connected entities

Interventions
Placebo Effect
Conditions
Major Depressive Disorder
Outcomes
Remission

Source

PMC3111899
Do early changes in the HAM-D-17 anxiety/somatization factor items affect treatment outcome among depressed outpatients? Comparison of two controlled trials of St John’s Wort (Hypericum Perforatum) versus an SSRI
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