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Finding improvement
In the pooled hypericum arms (n=147), early improvement in somatic-gastrointestinal (p<0.001, r2=0.262) and hypochondriasis (p=0.004, r2=0.218) items from baseline to week 1 significantly predicted remission at endpoint, after controlling for baseline severity, and both survived Bonferroni correction.
Effect sizesomatic-GI: p<0.001, r2=0.262; hypochondriasis: p=0.004, r2=0.218
ComparatorNon-improvement in somatic-GI/hypochondriasis items at week 1 within the same treatment group
Effect summaryimprovement; somatic-GI: p<0.001, r2=0.262; hypochondriasis: p=0.004, r2=0.218

Connected entities

Interventions
Hypericum perforatum
Conditions
Major Depressive Disorder
Outcomes
Remission

Source

PMC3111899
Do early changes in the HAM-D-17 anxiety/somatization factor items affect treatment outcome among depressed outpatients? Comparison of two controlled trials of St John’s Wort (Hypericum Perforatum) versus an SSRI
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