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Finding improvement
In the pooled SSRI arms (sertraline and fluoxetine combined, n=145), early improvement in the HAM-D-17 anxiety-psychic item from baseline to week 1 was significantly associated with remission at study endpoint, after controlling for baseline depression severity (p<0.001, r2=0.184), and this survived Bonferroni correction.
Effect sizep<0.001, r2=0.184
ComparatorNon-improvement in anxiety-psychic item at week 1 within the same treatment group
Effect summaryimprovement; p<0.001, r2=0.184

Connected entities

Interventions
SsrI endonuclease
Conditions
Major Depressive Disorder
Outcomes
Remission

Source

PMC3111899
Do early changes in the HAM-D-17 anxiety/somatization factor items affect treatment outcome among depressed outpatients? Comparison of two controlled trials of St John’s Wort (Hypericum Perforatum) versus an SSRI
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