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Finding
Finding
improvement
Off-medication UPDRS motor scores improved by 12.3 points in the DBS group versus 1.7 points in the best medical therapy group at 6 months based on blinded assessments, with 71% of DBS patients versus 32% of BMT patients achieving clinically meaningful improvement.
| Effect size | -12.3 points (DBS) vs -1.7 points (BMT) on UPDRS motor score |
| Follow-up | 6 months |
| Comparator | Best medical therapy actively managed by movement disorder neurologists |
| Effect summary | improvement; -12.3 points (DBS) vs -1.7 points (BMT) on UPDRS motor score |
| Effect modifiers | [{"modifier": "Age (>=70 vs <70 years)", "interaction_p": "", "direction": "null", "stratum_details": "Older patients: 61% vs 27% clinically meaningful improvement (P<.006). Slightly lower than overall (71% vs 32%) but still highly significant.", "plain_language": "Older patients still benefited substantially from DBS, though the percentage achieving clinically meaningful improvement was slightly lower.", "annotation_notes": "No formal interaction test reported."}] |
Connected entities
Interventions
Outcomes
Source
PMC2814800
Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson Disease A Randomized Controlled Trial