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Finding
Finding
improvement
Patients receiving bilateral deep brain stimulation gained a mean of 4.6 hours per day of on time without troubling dyskinesia at 6 months, compared with no change in the best medical therapy group.
| Effect size | 4.6 h/d gain (DBS) vs 0 h/d (BMT); between-group difference 4.5 h/d |
| CI | 95% CI, 3.7-5.4 h/d |
| Follow-up | 6 months |
| Comparator | Best medical therapy actively managed by movement disorder neurologists |
| Effect summary | improvement; 4.6 h/d gain (DBS) vs 0 h/d (BMT); between-group difference 4.5 h/d; CI: 95% CI, 3.7-5.4 h/d |
| Effect modifiers | [{"modifier": "Age (>=70 vs <70 years)", "interaction_p": "", "direction": "null", "stratum_details": "Older patients: 3.8 h/d gain vs -0.5 h/d (P<.001). Benefit magnitude slightly smaller but still highly significant.", "plain_language": "Deep brain stimulation worked for older patients too, though the gain was slightly smaller (3.8 vs 4.6 hours of good time per day).", "annotation_notes": "Age stratification was pre-specified (randomization stratified by <70 vs >=70). No formal interaction test reported, but both strata showed significant improvement."}] |
Connected entities
Interventions
Outcomes
Populations
Source
PMC2814800
Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson Disease A Randomized Controlled Trial