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Finding improvement
In pregnant patients with mild chronic hypertension, mean blood pressure <130/80 mmHg was associated with a 55% lower risk of the primary composite outcome compared to mean BP 130-139/80-89 mmHg, with consistent results after adjustment for confounders.
Effect sizeaRR 0.45
CI95% CI 0.38-0.54
ComparatorMean blood pressure 130-139/80-89 mmHg (Stage 1 hypertension range) during pregnancy
Effect summaryimprovement; aRR 0.45; CI: 95% CI 0.38-0.54
Effect modifiers[{"modifier": "CHAP trial arm assignment (active treatment vs standard/control)", "interaction_p": "p<0.01", "direction": "amplifies", "stratum_details": "Active arm: aRR 0.35 (95% CI 0.27-0.46); Control arm: aRR 0.60 (95% CI 0.47-0.76)", "plain_language": "The benefit of lower blood pressure was stronger when patients were actively treated with antihypertensive medication, suggesting treatment plays a role beyond just having naturally lower blood pressure.", "annotation_notes": "Formal p-interaction <0.01. Both arms still showed significant benefit."}]

Connected entities

Interventions
Blood pressure management
Conditions
Mild chronic ulcerative colitis
Outcomes
Primary composite outcome: preeclampsia with severe features, indicated preterm birth, placental abruption, fetal/neonatal death
Populations
Pregnant Women

Source

PMC10840706
Perinatal Outcomes Associated With Management of Stage 1 Hypertension
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