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Sertraline

Also known as: 1-Naphthalenamine,1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)- Medication-containing treatments (COMB: CBT + sertraline; SRT: sertraline alone) over 12 weeks in youth ages 7-17 with anxiety disorders Product containing sertraline Product containing sertraline (medicinal product) Sertraline Sertraline (product) Sertraline (substance) Sertraline product Sertraline-containing product AD
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Findings (50)

None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Both combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported internalizing psychopathology, while CBT alone was not.

Effect: improvement; COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0

Size: COMB: b=-5.7, t=3.4; SRT: b=-6.8, t=4.0
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8
None
improvement

Combination treatment and sertraline monotherapy were superior to placebo at week 12 on parent-reported youth depressive symptoms, while CBT was not, with both COMB and SRT also superior to CBT.

Effect: improvement; COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Size: COMB: b= -3.9, t= -3.7; SRT: b= -3.0, t= -2.8

Papers (1)