Category: Prediabetes & Diabetes
| Intervention | Condition | Outcome / Effect | Source | ||
|---|---|---|---|---|---|
| 📊 |
Metformin
vs Placebo + identical lifestyle |
Polycystic Ovary Syndrome
Postmenopausal Women |
Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to plac
ovulation rate ratio 2.5 (whether ovulat |
— |
PMC3073705
6 months |
| 📊 |
Metformin
vs Placebo + identical lifestyle |
Polycystic Ovary Syndrome
Adolescents |
Testosterone levels were significantly lower compared to baseline in the metformin group at 3 months | — |
PMC3073705
6 months |
| 📊 |
Metformin
vs Placebo + identical lifestyle |
Polycystic Ovary Syndrome
Adolescents |
Metformin plus lifestyle produced significant weight loss from baseline (-3.4 kg, 95% CI: -5.3, -1.5
-3.4 kg from baseline in MET at 6 months |
— |
PMC3073705
6 months |
| 📊 |
Metformin
vs Placebo + identical lifestyle |
Polycystic Ovary Syndrome
Adolescents |
Lifestyle plus placebo showed significant improvement in AUC glucose compared to both baseline and m | ↕ |
PMC3073705
6 months |
| 📊 |
Metformin
vs Placebo + identical lifestyle |
Polycystic Ovary Syndrome
Postmenopausal Women |
Total bone mineral density increased significantly in the metformin group, though the clinical impac | ↑ |
PMC3073705
6 months |
| 📊 |
Metformin
vs Placebo + identical lifestyle |
Polycystic Ovary Syndrome
Postmenopausal Women |
There were no significant differences in the overall PCOS-specific quality of life well-being scores | — |
PMC3073705
6 months |
| 📊 |
Metformin
vs Placebo + identical lifestyle |
Polycystic Ovary Syndrome
Adolescents |
Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in t
6 MET dropouts for medication side effec Side effects: diarrhea more common, headaches more common, 6 dro |
↓ |
PMC3073705
6 months |
| 💬 | Taking metformin to manage blood sugar l | Polycystic Ovary Syndrome | Making healthy changes after a loss can be challenging but is commendable, and metformin may aid in |
Metformin combined with lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (whether ovulated) and 1.2 (number of ovulations given ovulation). (PMC3073705) Metformin plus lifestyle produced significant weight loss from baseline (-3.4 kg, 95% CI: -5.3, -1.5) at 6 months, but this was not significantly different from placebo plus lifestyle. (PMC3073705) Testosterone levels were significantly lower compared to baseline in the metformin group at 3 months, but this effect was not sustained at 6 months, indicating only a transient androgen-lowering effect. (PMC3073705) Metformin caused significantly more diarrhea and headaches compared to placebo, resulting in 6 dropouts in the metformin group due to medication side effects versus none in the placebo group. (PMC3073705) Anecdotal evidence from Reddit suggests that some individuals use metformin to manage blood sugar and support fertility efforts in PCOS, but this is not controlled clinical data. (Reddit)