The study found that severe CMCJ OA clusters in multigenerational families, indicating a genetic contribution to the disease. Identification of a candidate gene (CHSY3) suggests potential pathways for understanding the etiology of CMCJ OA.
The intervention led to immediate pain and stiffness reduction, sustained pain relief over 14 days, and improved recovery perception compared to placebo.
Participants experienced a reduction in the first peak of the knee adduction moment by 7.6% with toe-in gait and 11.0% with toe-out gait, along with a decrease in hip abduction moment during gait.
Positive outcomes include improved mobility, reduced pain, and enhanced quality of life following the appropriate surgical intervention, tailored to the specific needs of the patient based on their clinical presentation.