The expected positive outcomes include improvements in cognitive and motor functions, as well as changes in brain microstructure as measured by MRI. The study aims to provide preliminary evidence for the effectiveness of HD-DRUM in enhancing the quality of life for individuals with HD.
The study found that sleep stage instability and sleep maintenance insomnia in premanifest and early manifest HD are predictive of disease onset and severity. Greater sleep maintenance insomnia was associated with more significant cognitive deficits and higher levels of serum neurofilament-light (NfL), a biomarker of disease activity.
Participants with HD showed a significant increase in Contingent Negative Variation (CNV) amplitude in response to alpha-tACS, indicating enhanced mPFC engagement. Neurotypical controls exhibited decreased post-target response times following alpha-tACS, suggesting improved cognitive processing.
Increased access to dispensaries was associated with a higher proportion of adults receiving medical marijuana certifications, particularly for conditions with insufficient evidence.
The intervention had an 85% retention rate, with participants achieving a mean of 92.3% valid wear days. Participants wearing the device day and night showed significant improvements in steps and MET*min/week compared to those wearing it only during the day.
The review aims to systematically evaluate the positive outcomes of cognitive and physical interventions on cognitive function in HD, potentially leading to improved cognitive outcomes and quality of life for patients.