The combined iTBS and LYB intervention was found to be feasible and safe for individuals with mTBI and CP, with a completion rate of 71.4% for the sessions.
Improvement in emotional health and changes in effective connectivity in brain regions associated with emotional processing after rTMS treatment.
Significant improvement in dynamic balance post-training (p=0.001), with 45.7% of participants meeting or exceeding the minimal detectable change (MDC) on the Community Balance and Mobility Scale. Self-paced gait velocity also improved significantly (p=0.02), although only 9.5% of stroke participants exceeded the MDC on the 10-meter walk test.
The study found no significant changes in neurophysiological activity or cognitive performance in either the mTBI or control groups across the assessment time points, indicating that iTBS did not have the expected positive outcomes in this population.
The study aims to improve individualized treatment of posttraumatic headache by developing a predictive model that accounts for variability in treatment response, potentially leading to better management of headache disability in veterans.
Participants showed significant improvements in executive functioning and a positive impact on daily activities, with moderate effect sizes observed in psychometric measures. There was a notable reduction in the number of forsaken daily life activities six months post-intervention compared to controls.
Participants in the experimental group showed statistically significant improvements in episodic memory as measured by psychometric tests. Clinically significant enhancements in psychological well-being were observed, with 50% of participants improving to a stable well-being category six months post-intervention.
Improvements in executive function correlated with increased rsFC within the frontoparietal network and between the default mode and sensorimotor networks. Increased grey matter volume was observed in the right inferior frontal gyrus, associated with enhanced cognitive performance.
The study aims to establish a dosing schedule that effectively reduces heart rate and maintains cerebral perfusion pressure, potentially leading to improved outcomes in TBI patients.
Eight out of 10 patients achieved ketosis within a mean of 2.2 days, indicating the feasibility of the KD in this patient population.
The study aimed to provide initial evidence on the efficacy of biperiden in preventing post-traumatic epilepsy, with the hope that it could reduce the incidence of late seizures in patients with TBI. However, the results indicated insufficient evidence to conclusively support its use for this purpose, highlighting the need for further research.
Expected positive outcomes include improved generalization of compensatory strategies to untrained tasks, enhanced treatment of slowed IPS, and better adherence to rehabilitation regimens due to the engaging nature of the game-supported training.
The study found that the average time to return to play increased in 2020, indicating that the new guidelines may have been effective in extending recovery time for concussed players.
The study established feasibility and acceptability for MBLT in improving sleep quality, with adherence to the intervention exceeding 85%.
Clinically significant alterations in brain networks were identified, with high variability between patients, enabling the formulation of neuroscience-guided rehabilitation programs tailored to individual needs.
Significant functional recovery was observed in TBI patients post-PAC, as indicated by improvements in the Barthel Index, IADL, and EQ-5D scores, demonstrating enhanced daily living activities and overall quality of life.
The program successfully completed 14 PPI sessions supporting 17 projects, with positive feedback from researchers indicating that the involvement of brain injury survivors enriched the research process. The diversity of panel members was comparable to the general population, although further outreach is needed for underrepresented groups.
The study found that among TBI patients, 40.3% improved from unfavorable to favorable neurologic status at six months, while very few patients deteriorated from favorable to unfavorable status or died during the same period.
The study found that DC did not significantly decrease overall mortality or rates of poor outcomes. However, children above six years of age may experience some benefits from the procedure, as indicated by lower than predicted mortality rates in this subgroup.
Positive outcomes associated with HIT include improved survival rates, better functional recovery, and enhanced quality of life for TBI patients.
Significant improvements in cortical activations, increased corticospinal excitability, larger hand motor evoked potential (MEP) areas, and enhanced fine motor function were observed after the intervention and during follow-ups.