The ESDM intervention led to significant improvements in cognitive scores, communication, and daily living skills, particularly in children categorized as High Responders. The study identified three subgroups based on cognitive trajectories, with some children showing nearly no cognitive delay by the end of treatment.
Individuals with non-carrier status for rare variants showed greater improvements in social skills from standard care compared to those with variants. SSGT was highlighted as potentially more beneficial for individuals with rare variants.
The emotion classifier demonstrated superior performance in recognizing emotions compared to existing platforms, supporting the hypothesis that a model trained on pediatric data can enhance emotion recognition for children with ASD. This suggests a potential for improved precision therapy at home.
The study hypothesizes that the RSA biofeedback intervention will lead to increased cardiac vagal modulation, improved behavioral and physiological parameters, and reduced stress levels in adolescents with ASD.
The meta-analysis indicates that CBT for anxiety is effective in reducing anxiety symptoms in autistic individuals, with moderate certainty in parent- and clinician-reported outcomes. The overall evidence for feasibility and acceptability of the identified strategies tends to be positive, suggesting that many adaptations can be easily implemented in mental health services.
Increased salivary oxytocin levels were observed 24 hours post-treatment, along with reduced DNA methylation and improved feelings of secure attachment in children receiving oxytocin compared to placebo.
The study found a significant positive correlation between cutaneous tactile sensation and balance performance, indicating that improved tactile sensation may lead to better balance scores in children with ASD.
The test group showed a 1.7-fold improvement in receptive language scores and a 1.4-fold improvement in expressive language scores compared to the control group, indicating significant language acquisition improvements through PFS training.
The study identifies significant differences in gaze fixation and transition patterns between children with ASD and neurotypical children during gameplay. Additionally, the deep learning model shows mild predictive power in identifying ASD based on gaze indicators.
The treatment resulted in improved autonomic stress regulation, as evidenced by increased heart rate variability, and enhanced amygdala coupling to regions of the salience network, indicating potential benefits in social salience processing.
86% of children experienced improvements in sleep onset, 54% in sleep duration, and 45% in night awakenings. Additionally, melatonin improved daytime behaviors in over 28% of the children.
The study aims to demonstrate that rTMS can safely reduce hyper-plasticity in the primary sensory cortex, which may lead to improved tactile reactivity and overall functioning in autistic individuals.
The study found improvements in affective characteristics across both groups, with increases in resting activity in the anterior cingulate cortex and right inferior temporal gyrus. Correlations were observed between brain activation patterns during SCP differentiation and the affective improvements reported by parents, indicating a potential link between neurofeedback training and emotional regulation.
Children with insomnia exhibited higher rates of healthcare utilization, including increased hospitalizations and emergency room visits. Treating insomnia may lead to improvements in sleep and a reduction in behavioral symptoms associated with ASD.
Approximately two-thirds of patients with ASD reported improvement in sleep problems after melatonin treatment, indicating its effectiveness in this population.
Expected improvements in Autism Treatment Evaluation Checklist scores, heart rate variability, gait, and reduced parenting stress index after the intervention.
Lithium treatment showed potential in rescuing the downregulated WNT/β-catenin signaling pathway and alleviating neurodevelopmental deficits associated with MARK2 variants in both cellular and tissue models.
The implementation of a genomics-informed model resulted in significant clinical benefits, including direct changes to management for all patients with pathogenic variants, increased rates of cascade testing, family counseling, medication changes, and specialty referrals.
The study found that bumetanide treatment significantly reduced the severity of ASD symptoms, as evidenced by improved scores on the CARS and Clinical Global Impressions Scale (CGI) - Global Improvement (CGI-I) after 3 months. The clinical improvement was associated with a decrease in insular GABA levels in the bumetanide group.
The study found that supervised HRVB led to a late increase in cardiac vagal modulation, with participants reporting significantly lower symptoms of stress after the home-based training period, regardless of prior training type.
There was a significant decrease in the Childhood Autism Rating Scale (CARS) score in children receiving Nichi Glucan compared to the control group, indicating improvement in behavioral patterns. Additionally, plasma levels of alpha-synuclein were significantly higher in the Nichi Glucan group, suggesting a potential link between the supplement and neurobiological changes.
Suggestive evidence indicated that higher absolute circulating α-tocopherol levels may reduce the risk of schizophrenia, although this was not statistically significant after correction for multiple testing.
Following the training, boys with FXS showed normalization of functional connectivity differences compared to boys with ASD, indicating an improvement in social gaze behavior and associated brain connectivity.
The study highlights the prevalence of psychiatric medication use among individuals with ASD, with a significant portion receiving treatment for depression, although the long-term effectiveness of these treatments remains a concern.
Participants showed a 14% improvement in facial emotion recognition accuracy, with some self-reported enhancements in social interactions post-training.
Most adaptations and bespoke interventions were found to be acceptable and feasible, with qualitative evidence indicating that specific adaptations (like visualization in CBT) were perceived as helpful by participants. The introduction of autism-specific training for clinicians was also seen as beneficial.