Comprehensive analysis of omega-3 supplementation for eye health and macular degeneration prevention
Works best when used consistently for weeks/months. Heat/humidity in shipping may affect pill quality.
We earn a commission if you make a purchase, at no additional cost to you.
Results may be best for dry eyes or certain retinal conditions. Benefits more likely with consistent, long-term use.
We earn a commission if you make a purchase, at no additional cost to you.
Recommended to refrigerate after opening. Manufacturer's certifications are not the same as independent lab verification.
We earn a commission if you make a purchase, at no additional cost to you.
General Health: 250-500 mg/day DHA+EPA
Eye Health Studies: ~1000 mg/day commonly used
AREDS2 Trial: 650mg EPA + 350mg DHA daily
Most studies use higher doses than general recommendations for targeted eye health benefits.
Triglyceride (TG) Form: Better absorbed than ethyl ester form
Third-Party Testing: Look for purity verification
Storage: Refrigerate after opening to prevent rancidity
Reputable brands specify the molecular form and provide certificates of analysis.
AREDS2 Trial Results: The most authoritative study found that DHA/EPA supplementation did not provide additional benefit in reducing progression to advanced AMD over the original AREDS formula (antioxidants plus zinc), even though it was safe.
Current Consensus: Omega-3 supplements alone should not replace clinically validated AREDS2 formulas for AMD, but may be part of a general eye-healthy diet.
Mixed Evidence: While observational studies show generally positive associations, controlled trials have shown inconsistent results.
Source: PubMed 28096126
Source: AREDS2 Summary
USP Verified: None of the featured products are confirmed USP Verified
Third-Party Testing: Nordic Naturals and BioSchwartz claim purity testing
cGMP Manufacturing: Look for current Good Manufacturing Practice certification
Check the USP database for the most current verifications.
Anticoagulants: Consult physician if taking blood thinners
Allergies: Check for fish/shellfish allergies
Dosage: Higher doses may increase bleeding risk
Always consult your healthcare provider before starting any supplement regimen.
Dr. Rhonda Patrick: Historically recommended Nordic Naturals as a reputable brand, emphasizing dietary sources (fatty fish) for optimal omega-3 intake.
Dr. Andrew Huberman: Generally recommends getting omega-3s from dietary sources for eye and brain health, or choosing reputable fish oil brands with third-party testing.
Clinical Guidance: For those with AMD or at high risk, the AREDS2 supplement remains the clinical standard. Omega-3 is not a replacement but may complement a comprehensive eye health strategy.
Bottom Line: Omega-3 may support general eye health, but evidence for AMD prevention is mixed. Focus on proven interventions like AREDS2 formula, healthy diet, and regular eye exams.